A couple caveats

For the sake of this discussion I will assume all possible work would pay equally and thus avoid the opportunity cost of Earning to give. Issues of pay cannot be ignored normally, but this allows us to focus on what the problem of the work itself.

Also, this type of optimization is restricted to discussions of how to do as much good as one can for the world. Many parts of one’s life should not be subject to this type of optimization, and I would argue that that is the path to being Over-optimization|optimal