Three high level itineraries

Sultanahmet + Beyoglu

Get lodging near Taksim Square in Beyoglu and drop off bags

Activities in Sultanahmet until ~6pm

Do dinner and nightlife in Beyoglu

Walk or taxi back to lodging

Sultanahmet + Kadikoy + Beyoglu

Get lodging near Taksim Square in Beyoglu and drop off bags

Go directly to Sultanahmet and do activities there until ~6pm

Take the ferry from Eminönü to Kadikoy

Do dinner in Kadikoy

Take the metro (Marmaray) to Beyoglu

Do nightlife in Beyoglu

Walk or taxi back to lodging

Sultanahmet + boat tour + Beyoglu

Get lodging near Taksim Square in Beyoglu and drop off bags

Go directly to Sultanahmet and do activities there until ~6pm

Do a Bosphorus boat tour

Do dinner and nightlife in Beyoglu

Walk or taxi back to lodging